Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
intestine | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? | |
sphingomyelin + H2O | - |
Rattus norvegicus | N-acylsphingosine + choline phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
A-SMase | - |
Homo sapiens |
A-SMase | - |
Rattus norvegicus |
acid SMase | - |
Homo sapiens |
acid SMase | - |
Rattus norvegicus |
acid sphingomyelinase | - |
Homo sapiens |
acid sphingomyelinase | - |
Rattus norvegicus |
alk-SMase | - |
Homo sapiens |
alk-SMase | - |
Rattus norvegicus |
alkaline SMase | - |
Homo sapiens |
alkaline SMase | - |
Rattus norvegicus |
N-SMase | - |
Homo sapiens |
N-SMase | - |
Rattus norvegicus |
neutral sphingomyelinase | - |
Homo sapiens |
neutral sphingomyelinase | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | acid SMase protein is decreased by 20% in both Hep-G2 and Caco-2 cells at 0.1 mM ezetimibe | down |
Rattus norvegicus | acid SMase protein is decreased by 25% in the intestine and by 34% in the liver at 0.1 mM ezetimibe | down |
Homo sapiens | ezetimibe up to 0.05 mM has no effects on acid phosphatase activity in both Hep-G2 and Caco-2 cells, no change of alkaline phosphatase activity is identified by ezetimibe | additional information |